Fact about fat cells
Owning 100 billion fat cells in your body because of the weight gain may seem scary. The good news is that you can always lose weight once your fat cells have grown and will be multiplied. In fact, when you lose weight, your fat cells shrink. Although the total number of fat cells declines only slightly (if at all), these cells become less metabolically active and stay in your body, they expect you to take a meal high in calories to grow again.

That means it is better to try to maintain a normal weight rather than take and lose weight through weight loss plans that are fast (temporary solutions). A person who maintained a normal weight (which was relatively thin) all his life will be easier to stay at this weight than another person whose fat cells were grown and multiplied.
The adipose tissue attracts cells that promote inflammation
Apart from how you feel bad when you take a few kilograms, there are also internal complications due to excess fat.
Adipose tissue attracts immune system cells called macrophages, which promote inflammation in the body. So if you have excess fat, your body begins to produce an immune response similar to the reaction that your body shows when you catch a cold or are injured.
The primary purpose of inflammation in the body is fighting infection. So, your body sees the calories of excess fat (you eat from food calories too) as an invasion into the body.
But do not worry, you do not have to abandon your favorite foods on. Studies show that lowering your total body weight as low as 10% (if you are overweight) can improve your health and limit the immune response to clear your body because of excess weight.